Callosal morphology in schizophrenia: what can shape tell us about function and illness?
نویسندگان
چکیده
Examination of the corpus callosum provides a window to cortical brain change in brain disorders. Combining volumetric with microstructural analysis allows a greater understanding of the biology underpinning change, and examining callosal structure alongside the structure of the cortical regions it interconnects may allow us to understand the true significance of callosal change in psychiatric disorders.
منابع مشابه
Callosal morphology in schizophrenia : what can shape tell us about function and illness ? {
The corpus callosum (Latin: ‘tough body’) is the human brain’s largest white matter tract, and its largest commissure. The callosum was first named by Galen of Pergamum in ancient Rome, at the beginning of the first century AD, among a range of other central nervous system structures. Up until the 16th century, it was generally felt to be a supporting or ‘scaffolding’ structure only. In 1543, A...
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BACKGROUND The shape of the corpus callosum may differ in schizophrenia, although no study has compared first-episode with established illness. AIMS To investigate the size and shape of the corpus callosum in a large sample of people with first-episode and established schizophrenia. METHOD Callosal size and shape were determined using high-resolution magnetic resonance imaging on 76 patient...
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Patients with schizophrenia exhibit abnormalities in midsagittal corpus callosum area, shape, and/or displacement. Our goal was to confirm these findings and to establish the genetic and nongenetic contributions to altered callosal morphology in schizophrenia. Relationships between ventricular enlargements potentially contributing to callosal displacements were assessed as a secondary goal. Hig...
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ورودعنوان ژورنال:
- The British journal of psychiatry : the journal of mental science
دوره 204 1 شماره
صفحات -
تاریخ انتشار 2014